Our Faculty : Primary Faculty

Roland Jurecic, Ph.D.

Dr. Jurecic’s research team has made a number of important contributions to science including: 1) discovery of new E3 ubiquitin ligase which controls hematopoietic progenitor cell differentiation into myeloerythroid lineages; 2) cloning and functional characterization of the Pumilio family of RNA-binding proteins which regulate maintenance and self-renewal of HSCs, germline and other stem cells types form Drosophila to humans; 3) the role of Wnt5a in negative regulation of B cell proliferation, normal T cell development, and tumor suppression in hematopoietic tissues; and 4) discovery that multipotent hematopoietic cells consist of interconvertible subsets which coexist in dynamic equilibrium.

Current Research Interests
1. Multi-Target Immunosuppressive Approach for Treatment of acquired Bone Marrow Failure (BMF) and immune-mediated Aplastic Anemia.
2. Characterization and mitigation of long-term adverse effects of cancer chemotherapy on the function of the hematopoietic and immune systems and their responses to infections.
3. Mitigation of cancer chemotherapy-induced secondary malignancies.
4. Functional heterogeneity and interconvertibility of HSCs.
5. Mitigation of acute and chronic adverse effects of radiation on the hematopoietic system and HSCs with anti-inflammatory β2 integrin agonists.

Research Profile
Pubmed Link