Our Publications

2018 Publications

Ascherman DP, Zang Y, Fernandez I, Clark ES, Khan WN, Martinez L, Greidinger EL. An Autoimmune Basis for Raynaud’s Phenomenon: Murine Model and Human Disease. Arthritis Rheumatol. 2018 Sep;70(9):1489-1499. doi: 10.1002/art.40505. Epub 2018 Jul 25. PubMed PMID: 29569858; PubMed Central PMCID: PMC6115278.

Asumda FZ, Hatzistergos KE, Dykxhoorn DM, Jakubski S, Edwards J, Thomas E, Schiff ER: Differentiation of Hepatocyte-like Cells from Human Pluripotent Stem Cells Using Small Molecules.Differentiation. 2018 Mar 27;101:16-24.

Bahnan W, Boucher J, Gayle P, Shrestha N, Rosen M, Aktas B, Adkins B, Ager A, Khan W, Schesser K. The eIF2α kinase Heme Regulated Inhibitor (HRI) protects the host from infection by regulating intracellular pathogen trafficking. Infection and Immunity. 2018 Feb 20. PMID: 29311243.

Bai F, McCormack RM, Hower S, Plano GV, Lichtenheld M, Munson GP. Perforin-2 breaches the envelope of phagocytosed bacteria allowing antimicrobial effectors access to intracellular targets. JImmunol 2018 Nov. 1; 201(9):2710-20, PMID: 30249808.

Birrell, G, Heffernan, G, Schiehser, G, Anderson, J, Ager, A, Morales, P, MacKenzie, D, Breda, K, Chavchich, M, Jacobus, L, Shanks, D, Jacobus, D, Edstein, M. Characterization of the Preclinical Pharmacology of the New 2-Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention. Antimicrob Agents Chemother. 62(4):e01335-17, 2018.

Carrico AW, Cherenack EM, Roach ME, Riley ED, Oni O, Dilworth SE, Shoptaw S, Hunt P, Roy S, Pallikkuth S, Pahwa S., Substance-associated elevations in monocyte activation among methamphetamine users with treated HIV infection. AIDS. 2018 Mar 27;32(6):767-771. doi: 10.1097/QAD.0000000000001751.

Carrico AW, Flentje A, Kober K, Lee S, Hunt P, Riley ED, Shoptaw S, Flowers E, Dilworth SE, Pahwa S, Aouizerat BE.Recent stimulant use and leukocyte gene expression in methamphetamine users with treated HIV infection. Brain Behav Immun. 2018 Jul;71:108-115. doi: 10.1016/j.bbi.2018.04.004. Epub 2018 Apr 18. PMID: 29679637

Cavallin LE, Ma Q, Naipauer J, Gupta S, Kurian M, Locatelli P, Romanelli P, Nadji M, Goldschmidt-Clermont PJ, Mesri EA*.(2018) KSHV-induced ligand mediated activation of PDGF receptor-alpha drives Kaposi’s sarcomagenesis. PLOS Pathogens 14(7): e1007175

Copsel SN, Lightbourn CO, Barreras H, Lohse I, Wolf D, Bader CS, Manov J, Kale BJ, Shah D, Brothers SP, Perez VL, Komanduri KV, Wahlestedt C, Levy RB. BET Bromodomain Inhibitors Which Permit Treg Function Enable a Combinatorial Strategy to Suppress GVHD in Pre-clinical Allogeneic HSCT. Front Immunol. 2019 Jan 24;9:3104. doi: 10.3389/fimmu.2018.03104. eCollection 2018.

Copsel, Sabrina, Dietlinde Wolf, Brandon Kale, Henry Barreras, Casey O. Lightbourn, Cameron S. Bader, W. Alperstein, Norman H. Altman, Krishna V. Komanduri, Robert B. Levy, Very Low Numbers of CD4+FoxP3+ Tregs Expanded in Donors via TL1A-Ig and Low Dose IL-2 Exhibit a Distinct Activation / Functional Profile and Suppress GVHD in a Pre-clinical Model. Biol. Blood and Marrow Transplantation, Biol Blood Marrow Transplant. 2018 Sep;24(9):1788-1794. doi: 10.1016/j.PMID: 29751114.

Debose-Scarlet A, Ayala GP, Schiff ER, Thomas E: Obstacles to successful treatment of hepatitis C in uninsured patients from a minority population. J Transl Med. 2018 Jun 28;16(1):178.

Diaz LA, Altman NH, Khan W, Serhan CN, Adkins B. Specialized Proresolving Mediators Rescue Infant Mice from Lethal Citrobacter rodentium Infection and Promote Immunity against Reinfection. Infect Immun. 2017 Sep 20;85(10). pii: e00464-17. doi: 10.1128/IAI.00464-17. Print 2017 Oct. Erratum in: Infect Immun. 2018 Sep 21;86(10):. PubMed PMID: 28694292; PubMed Central PMCID: PMC5607424

Dietlinde Wolf, Cameron S. Bader, Henry Barreras, Sabrina Copsel, Brent J. Pfeiffer, Casey O. Lightbourn, Norman H. Altman, Krishna V. Komanduri, and Robert B. Levy, Superior early immune reconstitution using Treg expanded donor cells versus PTCy in pre-clinical HSCT. JCI Insight. 2018 Oct 18;3(20). pii: 121717. doi: 10.1172/jci.insight.121717. [Epub ahead of print]

Ding, Yan, Hongai Li, Xiaojie He, Wang Liao, Zhuwen Yi, Jia Yi, Zhibin Chen, Daniel J. Moore, Yajun Yi, Wei Xiang. Identification of a gene-expression predictor for diagnosis and personalized stratification of lupus patients. PLoS One. 13(7):e0198325. PMID: 29975701. 2018.

Enkhmaa B, Anuurad E, Zhang W, Li CS, Kaplan R, Lazar J, Merenstein D, Karim R, Aouizerat B, Cohen M, Butler K, Pahwa S, Ofotokun I, Adimora AA, Golub E, Berglund L. Effect of antiretroviral therapy on allele-associated Lp(a) level in women with HIV in the Women’s Interagency HIV Study. J Lipid Res. 2018 Oct;59(10):1967-1976. doi: 10.1194/jlr.P084517. Epub 2018 Jul 16.

Frasca D, Blomberg BB, Fuldner R, Prabhudas M. “Aging and immunity” symposium: Meeting report. Exp Gerontol.,105: 1-3, 2018.

Frasca D, Diaz A, Romero M, Blomberg BB. Secretion of autoimmune antibodies in the human subcutaneous adipose tissue. PloS one. 2018; 13(5):e0197472

Frasca D. Senescent B cells in aging and age-related diseases: their role in the regulation of antibody responses. Exp Gerontol., 107: 55-58, 2018.

Garg B, Giri B, Modi S, Sethi V, Castro I, Umland O, Ban Y, Lavania S, Dawra R, Banerjee S, Vickers S, Merchant NB, Chen SX, Gilboa E, Ramakrishnan S, Saluja A, Dudeja V. NFkappaB in Pancreatic Stellate Cells Reduces Infiltration of Tumors by Cytotoxic T Cells and Killing of Cancer Cells, via Upregulation of CXCL12. Gastroenterology. 2018, in press

Gensous N, Franceschi C, Blomberg BB, Pirazzini C, Ravaioli F, Gentilini D, Di Blasio AM, Garagnani P, Frasca D, Bacalini MG. Responders and non-responders to influenza vaccination: a DNA methylation approach on blood cells. Exp Gerontol.,105: 94-100, 2018.

George VK, Pallikkuth S, Pahwa R, de Armas LR, Rinaldi S, Pan L, Pahwa S., Circulating inflammatory monocytes contribute to impaired influenza vaccine responses in HIV-infected participants. AIDS. 2018 Jun 19;32(10):1219-1228. doi: 10.1097/QAD.0000000000001821. PMID: 29683844

Grosgebauer K, Salinas J, Sharkey M, Roach M, Pallikkuth S, Dilworth SE, Pahwa S, Koru-Sengul T, Stevenson M, Carrico AW., Psychosocial Correlates of Monocyte Activation and HIV Persistence in Methamphetamine Users. J Neuroimmune Pharmacol. 2019 Mar;14(1):16-22. doi: 10.1007/s11481-018-9797-2. Epub 2018 Jul 25. PMID: 30046962

Hunte R, Alonso P, Thomas R, Bazile CA, Ramos JC, van der Weyden L, Dominguez-Bendala J, Khan WN, Shembade N. CADM1 is essential for KSHV-encoded vGPCR-and vFLIP-mediated chronic NF-κB activation. PLoS Pathog. 2018 Apr 26;14(4):e1006968. doi: 10.1371/journal.ppat.1006968. eCollection 2018 Apr. PubMed PMID: 29698475; PubMed Central PMCID: PMC5919438.

Hunte, Richard, Patricia Alonso, Juan Carlos Ramos, Louise van der Weyden and Noula Shembade. CADM1 is essential for KSHV-encoded vGPCR- and vFLIP-mediated chronic NF-κB activation PLoS Pathog. 2018 Apr 26;14(4) Press Release.

Hyun J, McMahon R, Green M, Stevenson M, Pahwa S, Thomas E: Activation of TREM1 Signaling in Kupffer Cells Following HIV and HCV Stimulation Augments Hepatic Inflammatory Responses.Submitted to PLOS Pathogens.

Manzoli V, Villa C, Bayer AL, Morales L, Molano DR, Torrente Y, Ricordi C, Hubbell JA, Tomei AA. Immunoisolation of Murine Islet Allografts in Vascularized Sites through Conformal Coating with Polyethylene Glycol. American Journal of Transplantation. Mar; 18(3):590 DOI: 10.1111/ajt.14547. (2018)

Miska Jason , Lui Jen Bon , Toomer Kevin H. , Priyadharshini Devarajan, Xiaodong Cai, JeanMarie Houghton, Diana M. Lopez, aria T. Abreu, Gaofeng Wang, and Zhibin Chen. Initiation of Inflammatory Tumorigenesis by CTLA4 Insufficiency Due to Type 2 Cytokines. Journal of Experimental Medicine. 215: 841-858. PMID: 29374027. 2018.

Mitchell CD, Dominguez S, Roach M, George V, Rinaldi S, Fischl M, Potter J, Tyson B, Pahwa S., Microbial Translocation and Immune Activation in HIV-1 Infected Pregnant Women. Curr HIV Res. 2018;16(3):208-215 Microbial Translocation and Immune Activation in HIV-1 Infected Pregnant Women. Mitchell CD, Dominguez S, Roach M, George V, Rinaldi S, Fischl M, Potter J, Tyson B, Pahwa S. Curr HIV Res. 2018;16(3):208-215. doi:0.2174/1570162X16666180731145011.PMID: 30062968

Moysi E, Pallikkuth S, De Armas LR, Gonzalez LE, Ambrozak D, George V, Huddleston D, Pahwa R, Koup RA, Petrovas C, Pahwa S. , Altered immune cell follicular dynamics in HIV infection following influenza vaccination. J Clin Invest. 2018 Jul 2;128(7):3171-3185. doi: 10.1172/JCI99884. Epub 2018 Jun 18. PMID: 29911996

Nichols AJ, Gonzalez A, Clark ES, Khan WN, Rosen AC, Guzman W, Rabinovitz H, Badiavas EV, Kirsner RS, Ioannides T. Combined Systemic and Intratumoral Administration of Human Papillomavirus Vaccine to Treat Multiple Cutaneous Basaloid Squamous Cell Carcinomas. JAMA Dermatol. 2018 Aug 1;154(8):927-930. doi: 10.1001/jamadermatol.2018.1748. PubMed PMID: 29971321; PubMed Central PMCID: PMC6143030.

Nyhoff LE, Clark ES, Barron BL, Bonami RH, Khan WN (corresponding author), Kendall PL. (corresponding author), Bruton’s Tyrosine Kinase Is Not Essential for B Cell Survival beyond Early Developmental Stages. J Immunol. 2018 Apr 1;200(7):2352-2361. doi: 10.4049/jimmunol.1701489. Epub 2018 Feb 26. PubMed PMID: 29483358; PubMed Central PMCID: PMC6177684.

Pala O, Diaz A, Blomberg BB, Frasca D. B lymphocytes in Rheumatoid Arthritis and Effects of anti-TNF- α agents on B lymphocytes: Review of the literature. Clin Therapeutics, 40: 1034-1045, 2018.

Pallikkuth S, De Armas LR, Pahwa R, Rinaldi S, George VK, Sanchez CM, Pan L, Dickinson G, Rodriguez A, Fischl M, Alcaide M, Pahwa S. Impact of aging and HIV infection on serologic response to seasonal influenza vaccination. AIDS. 2018 Jun 1;32(9):1085-1094.

Pallikkuth S, Pahwa R, Kausalya B, Saravanan S, Pan L, Vignesh R, Iqbal S, Solomon SS, Murugavel KG, Poongulali S, Kumarasamy N, Pahwa S. Cardiac morbidity in HIV infection is associated with checkpoint inhibitor LAG-3 on CD4 T cells. PLoS One. 2018 Oct 31;13(10):e0206256. doi: 10.1371/journal.pone.0206256. eCollection 2018.

Puplampu-Dove, Y. Gefen, T., Rajagopalan, A., Muheramejic, D., Schrand, B., Gilboa, E., Potentiating tumor immunity using aptamer-targeted RNAi to render CD8+ T cells resistant to TGFβ inhibition. OncoImmunol. 2018, 7: e1349588

Riley RL, Khomtchouk K, Blomberg BB. 2018. Inflammatory immune cells may impair the preBCR checkpoint, reduce new B cell production, and alter the antibody repertoire in old age. Exp Gerontol. 105: 87-93.

Rivas, ZP, McCormack RM, Adkins B, Munson GP. CexE is a virulence factor of Citrobacterrodentium and present in enteric pathogens of humans. InfectImm. 2018. In revision

Rocca S, Zangari P, Cotugno N, De Rossi A, Ferns B, Petricone D, Rinaldi S, Giaquinto C, Bernardi S, Rojo P, Rossi P, Pahwa S, Nastouli E, Palma P; Human Immunodeficiency Virus (HIV)-Antibody Repertoire Estimates Reservoir Size and Time of Antiretroviral Therapy Initiation in Virally Suppressed Perinatally HIV-Infected Children. EPIICAL Consortium . J Pediatric Infect Dis Soc. 2018 Aug 28.

Rosario SA, Santiago GE, Mesri EA*, Verdun RE, Kaposi’s Sarcoma-Associated Herpesvirus-Encoded Viral IL-6 (vIL-6) Enhances Immunoglobulin Class-Switch Recombination. Front Microbiol. (2018) Dec 18;9:3119. doi: 10.3389/fmicb.2018.03119. eCollection 2018.PMID: 30619193
Schrand B, Clark E, Levay A, Capote AR, Martinez O, Brenneman R,, Castro, Iris, and Gilboa, E.. Hapten-mediated recruitment of polyclonal antibodies to tumors engenders antitumor immunity. Nature communications. 2018;9:3348

Sharabi,A., Tsokos, M.G., Ding, Y., Malek, T.R., Klatzmann, D., Tsokos, G.C. Regulatory T cells in the treatment of disease. Nat Rev Drug Discov. 2018 Oct 12. doi: 10.1038/nrd.2018.148

Souza, C.A., Richards, K.L., Park, Y., Schwartz, M., Torruellas Garcia, J., Schesser Bartra, S. and, G.V. Plano. The YscE/YscG chaperone and YscF N-terminal sequences target YscF to the Yersinia pestis type III secretion apparatus. Microbiology. 164:338-348, 2018.

Strbo N, Pastar I, Romero L, Chen V, Vujanac M, Sawaya AP, Jozic I, Ferreira ADF, Wong LL, Head C, Stojadinovic O, Garcia D, O’Neill K, Drakulich S, Taller S, Kirsner RS, Tomic-Canic M. Single cell analyses reveal specific distribution of anti-bacterial molecule Perforin-2 in human skin and its modulation by wounding and Staphylococcus aureus infection. Exp Dermatol. 2019 Jan 4.

Thomas E: Hepatitis B virus X protein: TRIMming antiviral defences in hepatocytes. Thomas E. Gut. 2018 Jan; 67(1):3-4.

Wang AW, Bouchard LC, Gudenkauf LM, Jutagir DR, Fisher HM, Jacobs JM, Blomberg BB, Lechner SC, Carver CS, Antoni MH. Differential psychological effects of cognitive-behavioral stress management among breast cancer patients with high and low initial cancer-specific distress. J Psychosom Res. 2018 Oct;113:52-57

Ward, N.C., Yu, A., Moro, A., Ban, Y., Chen, X., Hsiung, S., Keegan, J., Arbanas, J.M., Loubeau, M., Thankappan, A., Yamniuk, A.P., Davis, J.H., Struthers, M., Malek, T.R. IL-2/CD25: A long-acting IL-2-based biologic that targets the high affinity IL-2R on regulatory T cells. J Immunol. 2018 Nov 1;201(9):2579-2592

Wikramanayake TC, Hirt P, Almastadi M, Mitchell H, Tomic-Canic M, Romero L, Garcia D, Strbo N. Increased IL-17-expressing γδ T cells in seborrhoeic dermatitis-like lesions of the Mpzl3 knockout mice. Exp Dermatol. 2018 Dec;27(12):1408-1411.

Zangari P, Palma P, Cotugno N, Rojo P, Tagarro A, Pepponi I, De Rossi A, Kuhn L, Pahwa S, Cameron M, Nastouli E, Watters S, Marceline AG, McCoy LE, Persaud D, Violari A, Chan M, Babiker AG, Foster C, Ananworanich J, Giaquinto C, Rossi P., Report from the First EPIICAL (Early-treated Perinatally HIV-infected Individuals: Improving Children’s Actual Life with Novel Immunotherapeutic Strategies) General Assembly meeting, 9-11 November 2017, Rome, Italy. J Virus Erad. 2018 Jan 1;4(1):51-54. No abstract available. PMID: 29568555

Zhou Xin , Chen *Zhibin & Cai *Xiaodong . (*co-senior author). Identification of epigenetic modulators in human breast cancer by integrated analysis of DNA methylation and RNA-Seq data. Epigenetics. 2018 Aug 7:1-17 [Epub ahead of print]. PMID: 29940789. 2018.