Our Publications

2017 Publications

Altered homeostasis and development of regulatory T cell subsets represent an IL-2R-dependent risk for diabetes in NOD mice.
Dwyer CJ, Bayer AL, Fotino C, Yu L, Cabello-Kindelan C, Ward NC, Toomer KH, Chen Z, Malek TR. Sci Signal. 2017 Dec 19;10(510). pii: eaam9563. doi: 10.1126/scisignal.aam9563. PMID:29259102

The neonatal window of opportunity-early priming for life.
Renz H, Adkins BD, Bartfeld S, Blumberg RS, Farber DL, Garssen J, Ghazal P, Hackam DJ, Marsland BJ, McCoy KD, Penders J, Prinz I, Verhasselt V, von Mutius E, Weiser JN, Wesemann DR, Hornef MW. J Allergy Clin Immunol. 2017 Dec 14. pii: S0091-6749(17)31895-X. doi: 10.1016/j.jaci.2017.11.019. [Epub ahead of print] No abstract available. PMID: 29247715

Postoperative fasting after general anaesthesia: A survey of French anaesthesiology practices.
Le Pape S, Boisson M, Loupec T, FabienVigneau, Debaene B, Frasca D. Anaesth Crit Care Pain Med. 2017 Dec 9. pii: S2352-5568(17)30099-1. doi: 10.1016/j.accpm.2017.11.012. [Epub ahead of print] PMID: 29233755

Aging, Obesity, and Inflammatory Age-Related Diseases.
Frasca D, Blomberg BB, Paganelli R. Front Immunol. 2017 Dec 7;8:1745. doi: 10.3389/fimmu.2017.01745. eCollection 2017. Review. PMID: 29270179

Associations of Plasma Cytokine and Microbial Translocation Biomarkers With Immune Reconstitution Inflammatory Syndrome.
George V, Harrison L, Roach M, Li XD, Tierney C, Fischl MA, Aberg J, Tebas P, Asmuth DM, Pollard RB, Godfrey C, Pahwa S; AIDS Clinical Trials Group A5202 Study Team. J Infect Dis. 2017 Nov 27;216(9):1159-1163. doi: 10.1093/infdis/jix460. PMID: 29040604

The Folate Cycle As a Cause of Natural Killer Cell Dysfunction and Viral Etiology in Type 1 Diabetes.
Bayer AL, Fraker CA. Front Endocrinol (Lausanne). 2017 Nov 23;8:315. doi: 10.3389/fendo.2017.00315. eCollection 2017. PMID: 29218028

How changes in physical activity relate to fatigue interference, mood, and quality of life during treatment for non-metastatic breast cancer.
Fisher HM, Jacobs JM, Taub CJ, Lechner SC, Lewis JE, Carver CS, Blomberg BB, Antoni MH. Gen Hosp Psychiatry. 2017 Nov;49:37-43. doi: 10.1016/j.genhosppsych.2017.05.007. Epub 2017 May 29. PMID: 28583700

Aging effects on T-bet expression in human B cell subsets.
Frasca D, Diaz A, Romero M, D’Eramo F, Blomberg BB. Cell Immunol. 2017 Nov;321:68-73. doi: 10.1016/j.cellimm.2017.04.007. Epub 2017 Apr 24. PMID: 28457482

Small-Molecule Inhibitors of the CD40-CD40L Costimulatory Protein-Protein Interaction.
Chen J, Song Y, Bojadzic D, Tamayo-Garcia A, Landin AM, Blomberg BB, Buchwald P. J Med Chem. 2017 Nov 9;60(21):8906-8922. doi: 10.1021/acs.jmedchem.7b01154. Epub 2017 Oct 25. PMID: 29024591

Age-associated B cells (ABC) inhibit B lymphopoiesis and alter antibody repertoires in old age.
Riley RL, Khomtchouk K, Blomberg BB. Cell Immunol. 2017 Nov;321:61-67. doi: 10.1016/j.cellimm.2017.04.008. Epub 2017 Apr 26. PMID: 28535870

Immunoisolation of murine islet allografts in vascularized sites through conformal coating with polyethylene glycol.
Manzoli V, Villa C, Bayer AL, Morales LC, Molano RD, Torrente Y, Ricordi C, Hubbell JA, Tomei AA. Am J Transplant. 2017 Oct 25. doi: 10.1111/ajt.14547. [Epub ahead of print] PMID:29068143

T Follicular Helper Cells and B Cell Dysfunction in Aging and HIV-1 Infection.
Pallikkuth S, de Armas L, Rinaldi S, Pahwa S. Front Immunol. 2017 Oct 23;8:1380. doi: 10.3389/fimmu.2017.01380. eCollection 2017. Review. PMID: 29109730

Reevaluation of immune activation in the era of cART and an aging HIV-infected population.
de Armas LR, Pallikkuth S, George V, Rinaldi S, Pahwa R, Arheart KL, Pahwa S. JCI Insight. 2017 Oct 19;2(20). pii: 95726. doi: 10.1172/jci.insight.95726. [Epub ahead of print] PMID: 29046481

A TIM-3 Oligonucleotide Aptamer Enhances T Cell Functions and Potentiates Tumor Immunity in Mice.
Gefen T, Castro I, Muharemagic D, Puplampu-Dove Y, Patel S, Gilboa E. Mol Ther. 2017 Oct 4;25(10):2280-2288. doi: 10.1016/j.ymthe.2017.06.023. Epub 2017 Aug 8. PMID: 28800954

Rapamycin targets several pathophysiological features of immune-mediated bone marrow failure in murine models.
Weston WW, Jurecic V, Jurecic R. Haematologica. 2017 Oct;102(10):1627-1628. doi: 10.3324/haematol.2017.175497. No abstract available. PMID: 28965088

Specialized Proresolving Mediators Rescue Infant Mice from Lethal Citrobacter rodentium Infection and Promote Immunity against Reinfection.
Diaz LA, Altman NH, Khan W, Serhan CN, Adkins B. Infect Immun. 2017 Sep 20;85(10). pii: e00464-17. doi: 10.1128/IAI.00464-17. Print 2017 Oct. PMID: 28694292

Perturbation of B Cell Gene Expression Persists in HIV-Infected Children Despite Effective Antiretroviral Therapy and Predicts H1N1 Response.
Cotugno N, De Armas L, Pallikkuth S, Rinaldi S, Issac B, Cagigi A, Rossi P, Palma P, Pahwa S. Front Immunol. 2017 Sep 11;8:1083. doi: 10.3389/fimmu.2017.01083. eCollection 2017. PMID: 28955330

Adipose Tissue Inflammation Induces B Cell Inflammation and Decreases B Cell Function in Aging.
Frasca D, Blomberg BB. Front Immunol. 2017 Aug 28;8:1003. doi: 10.3389/fimmu.2017.01003. eCollection 2017. Review. PMID: 28894445

Social well-being is associated with less pro-inflammatory and pro-metastatic leukocyte gene expression in women after surgery for breast cancer.
Jutagir DR, Blomberg BB, Carver CS, Lechner SC, Timpano KR, Bouchard LC, Gudenkauf LM, Jacobs JM, Diaz A, Lutgendorf SK, Cole SW, Heller AS, Antoni MH. Breast Cancer Res Treat. 2017 Aug;165(1):169-180. doi: 10.1007/s10549-017-4316-3. Epub 2017 May 30. PMID: 28560656

Senescent B cells in aging and age-related diseases: Their role in the regulation of antibody responses.
Frasca D. Exp Gerontol. 2017 Jul 4. pii: S0531-5565(17)30430-8. doi: 10.1016/j.exger.2017.07.002. [Epub ahead of print] Review. PMID: 28687479

Cytokine Signaling in the Development and Homeostasis of Regulatory T cells.
Toomer KH, Malek TR. Cold Spring Harb Perspect Biol. 2017 Jun 15. pii: a028597. doi: 10.1101/cshperspect.a028597. [Epub ahead of print] PMID: 28620098

Immune development in HIV-exposed uninfected children born to HIV-infected women.
Miyamoto M, Gouvêa AFTB, Ono E, Succi RCM, Pahwa S, Moraes-Pinto MI. Rev Inst Med Trop Sao Paulo. 2017 Jun 1;59:e30. doi: 10.1590/S1678-9946201759030. PMID: 28591258

How does cytomegalovirus factor into diseases of aging and vaccine responses, and by what mechanisms?
Aiello AE, Chiu YL, Frasca D. Geroscience. 2017 Jun;39(3):261-271. doi: 10.1007/s11357-017-9983-9. Epub 2017 Jun 18. Review. PMID: 28624868

Cancer-testis antigen expression is shared between epithelial ovarian cancer tumors.
Garcia-Soto AE, Schreiber T, Strbo N, Ganjei-Azar P, Miao F, Koru-Sengul T, Simpkins F, Nieves-Neira W, Lucci J 3rd, Podack ER. Gynecol Oncol. 2017 Jun;145(3):413-419. doi: 10.1016/j.ygyno.2017.03.512. Epub 2017 Apr 6. PMID: 28392126

Metformin improves in vivo and in vitro B cell function in individuals with obesity and Type-2 Diabetes.
Diaz A, Romero M, Vazquez T, Lechner S, Blomberg BB, Frasca D. Vaccine. 2017 May 9;35(20):2694-2700. doi: 10.1016/j.vaccine.2017.03.078. Epub 2017 Apr 6. PMID: 28392139

Marked in Vivo Donor Regulatory T Cell Expansion via Interleukin-2 and TL1A-Ig Stimulation Ameliorates Graft-versus-Host Disease but Preserves Graft-versus-Leukemia in Recipients after Hematopoietic Stem Cell Transplantation.
Wolf D, Barreras H, Bader CS, Copsel S, Lightbourn CO, Pfeiffer BJ, Altman NH, Podack ER, Komanduri KV, Levy RB. Biol Blood Marrow Transplant. 2017 May;23(5):757-766. doi: 10.1016/j.bbmt.2017.02.013. Epub 2017 Feb 20. PMID: 28219835

Lipoprotein(a) and HIV: Allele-Specific Apolipoprotein(a) Levels Predict Carotid Intima-Media Thickness in HIV-Infected Young Women in the Women’s Interagency HIV Study.
Enkhmaa B, Anuurad E, Zhang W, Li CS, Kaplan R, Lazar J, Merenstein D, Karim R, Aouizerat B, Cohen M, Butler K, Pahwa S, Ofotokun I, Adimora AA, Golub E, Berglund L. Arterioscler Thromb Vasc Biol. 2017 May;37(5):997-1004. doi: 10.1161/ATVBAHA.117.309137. Epub 2017 Mar 23. PMID: 28336560

The Lower Limit of Regulatory CD4+ Foxp3+ TCRβ Repertoire Diversity Required To Control Autoimmunity.
Yu A, Dee MJ, Adeegbe D, Dwyer CJ, Altman NH, Malek TR. J Immunol. 2017 Apr 15;198(8):3127-3135. doi: 10.4049/jimmunol.1601966. Epub 2017 Mar 6. PMID: 28264971

Paradoxical aging in HIV: immune senescence of B Cells is most prominent in young age.
Rinaldi S, Pallikkuth S, George VK, de Armas LR, Pahwa R, Sanchez CM, Pallin MF, Pan L, Cotugno N, Dickinson G, Rodriguez A, Fischl M, Alcaide M, Gonzalez L, Palma P, Pahwa S. Aging (Albany NY). 2017 Apr;9(4):1307-1325. doi: 10.18632/aging.101229. PMID: 28448963

High Levels of Inflammatory Cytokines in the Reproductive Tract of Women with BV and Engaging in Intravaginal Douching: A Cross-Sectional Study of Participants in the Women Interagency HIV Study.
Alcaide ML, Rodriguez VJ, Brown MR, Pallikkuth S, Arheart K, Martinez O, Roach M, Fichorova RN, Jones DL, Pahwa S, Fischl MA. AIDS Res Hum Retroviruses. 2017 Apr;33(4):309-317. doi: 10.1089/AID.2016.0187. Epub 2017 Jan 3. PMID: 27897054

Radiation-Induced Enhancement of Antitumor T-cell Immunity by VEGF-Targeted 4-1BB Costimulation.
Schrand B, Verma B, Levay A, Patel S, Castro I, Benaduce AP, Brenneman R, Umland O, Yagita H, Gilboa E, Ishkanian A. Cancer Res. 2017 Mar 15;77(6):1310-1321. doi: 10.1158/0008-5472.CAN-16-2105. Epub 2017 Jan 12. PMID: 28082399

Induction of IL21 in Peripheral T Follicular Helper Cells Is an Indicator of Influenza Vaccine Response in a Previously Vaccinated HIV-Infected Pediatric Cohort.
de Armas LR, Cotugno N, Pallikkuth S, Pan L, Rinaldi S, Sanchez MC, Gonzalez L, Cagigi A, Rossi P, Palma P, Pahwa S. J Immunol. 2017 Mar 1;198(5):1995-2005. doi: 10.4049/jimmunol.1601425. Epub 2017 Jan 27. PMID: 28130496

Obesity induces pro-inflammatory B cells and impairs B cell function in old mice.
Frasca D, Diaz A, Romero M, Vazquez T, Blomberg BB. Mech Ageing Dev. 2017 Mar;162:91-99. doi: 10.1016/j.mad.2017.01.004. Epub 2017 Jan 19. PMID: 28111127

In old BALB/c mice, bone marrow pre-B cell and surrogate light chain reduction is associated with increased B cell reactivity to phosphorylcholine, but reduced T15 idiotype dominance.
Khomtchouk K, Alter S, Ratliff M, Blomberg BB, Riley RL. Mech Ageing Dev. 2017 Mar;162:53-62. doi: 10.1016/j.mad.2016.11.004. Epub 2016 Nov 19. PMID: 27876385

Isolation and Flow Cytometric Analysis of Human Endocervical Gamma Delta T Cells.
Strbo N, Romero L, Alcaide M, Fischl M. J Vis Exp. 2017 Feb 6;(120). doi: 10.3791/55038. PMID: 28287518

Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner.
Pinto M, Pickrell AM, Wang X, Bacman SR, Yu A, Hida A, Dillon LM, Morton PD, Malek TR, Williams SL, Moraes CT. Cell Death Differ. 2017 Feb;24(2):288-299. doi: 10.1038/cdd.2016.123. Epub 2016 Dec 2. PMID: 27911443

Post-surgical depressive symptoms and long-term survival in non-metastatic breast cancer patients at 11-year follow-up.
Antoni MH, Jacobs JM, Bouchard LC, Lechner SC, Jutagir DR, Gudenkauf LM, Blomberg BB, Glück S, Carver CS. Gen Hosp Psychiatry. 2017 Jan – Feb;44:16-21. doi: 10.1016/j.genhosppsych.2016.10.002. Epub 2016 Oct 22. PMID: 28041571

Rapid CD8+ Function Is Critical for Protection of Neonatal Mice from an Extracellular Bacterial Enteropathogen.
Siefker DT, Adkins B. Front Pediatr. 2017 Jan 9;4:141. doi: 10.3389/fped.2016.00141. eCollection 2016. PMID: 28119902

Aptamer-Targeted Attenuation of IL-2 Signaling in CD8+ T Cells Enhances Antitumor Immunity.
Rajagopalan A, Berezhnoy A, Schrand B, Puplampu-Dove Y, Gilboa E. Mol Ther. 2017 Jan 4;25(1):54-61. doi: 10.1016/j.ymthe.2016.10.021. Epub 2017 Jan 4. PMID: 28129128

Human peripheral late/exhausted memory B cells express a senescent-associated secretory phenotype and preferentially utilize metabolic signaling pathways.
Frasca D, Diaz A, Romero M, Blomberg BB. Exp Gerontol. 2017 Jan;87(Pt A):113-120. doi: 10.1016/j.exger.2016.12.001. Epub 2016 Dec 6. PMID: 27931848

Measurement of Effector Protein Translocation Using Phosphorylatable Epitope Tags and Phospho-Specific Antibodies.
Bartra SS, Plano GV. Methods Mol Biol. 2017;1531:111-119. PMID: 27837486

4PD Functionalized Dendrimers: A Flexible Tool for In Vivo Gene Silencing of Tumor-Educated Myeloid Cells.
Zilio S, Vella JL, De la Fuente AC, Daftarian PM, Weed DT, Kaifer A, Marigo I, Leone K, Bronte V, Serafini P. Journal of immunology (Baltimore, Md. : 1950). 2017; 198(10):4166-4177.
PubMed [journal] PMID: 28396317